Pharmacoepidemiology and Drug Safety (PDS), the official journal of ISPE, presents the Ronald D. Mann Best Paper Award each year to the strongest contribution within a given volume of the journal. The award for 2023 is presented to Dr. Neil Dhopeshwarkar and collaborators for their paper --- Combining Super Learner with high-dimensional propensity score to improve confounding adjustment: A real-world application in chronic lymphocytic leukemia. 

Super Learner (SL) was proposed to assist with high-dimensional propensity score (hdPS) covariate selection and was found to improve bias reduction and precision compared to hdPS alone in the simulated setting. This paper compared the performance of SL-hdPS with hdPS alone in the applied setting of a cohort study comparing bleeding rates between ibrutinib- and bendamustine-rituximab-treated individuals with chronic lymphocytic leukemia. The study findings provide support for the use of SL-hdPS in applied observational studies. 

In this webinar, Dr. Dhopeshwarkar will present study findings followed by comments by PDS regional editor for the Americas, Dr. Vincent Lo Re. The audience will not only have the opportunity to discuss the paper with Dr. Dhopeshwarkar but to also ask questions regarding the PDS editorial process with Dr. Lo Re.