Diversity and inclusion in interventional studies remains an ongoing concern, as highlighted by recent regulatory guidance in the U.S. The application of epidemiological methods are paramount to addressing issues in diversity and inclusion in both interventional and non-interventional research. The webinar will consist of three major components. The first section of the webinar, presented by Claudia Cabrera, will focus on health equity in clinical trial planning. The critical role of epidemiology and real-world evidence will be presented, and there will be a discussion of methods considerations including the clinical trial diversity index. The second portion of the webinar, presented by Paula Strassle, will address potential biases in observational data in the health equity setting. Issues of selection bias, differential missingness, and adjustment strategy will be presented along with and some proposed solutions. The third component of the webinar, presented by Macarius Donneyong, will focus on methodological frameworks for guiding the planning and implementation of health equity research in pharmacoepidemiology through the use of real-world data sources. A review of frameworks and methods for assessing health equity in pharmacoepidemiology will be provided, along with a discussion of how to evaluate real world databases for the suitability of health equity research. The webinar will conclude with a discussion of gaps and future directions and audience Q&A.