Observational Health Data Sciences and Informatics (OHDSI; http://ohdsi.org) is an open science community of researchers and international data network that aims to improve health by empowering a community to collaboratively generate the evidence that promotes better health decisions and better care. OHDSI conducts methodological research, develops open-source analytics tools, and applies scientific best practices to the design and execution of observational network analyses. This webinar will provide an overview of OHDSI and demonstrate how the research community has collaborated to generate real-world evidence to support clinical characterization, population-level effect estimation, and patient-level prediction.