Reporting to achieve transparent and replicable evidence from healthcare databases (REPEAT Initiative)
Speaker: Shirley Wang, PhD, Harvard Medical School/Brigham & Women's Hospital
Implementation of a pharmacoepidemiology study using non-randomized administrative claims or electronic health record data can involve many subtle design, analysis and operational decisions to create appropriately temporally anchored analytic cohorts from healthcare data that were not collected for research purposes.
Healthcare decision-makers have emphasized the need greater transparency in research that makes secondary use of databases. The REPEAT Initiative has embarked on several projects aimed at improving transparency, reproducibility and validity of database research. These projects include large scale replication of 150 published database studies, evaluation of the robustness of results to alternative design and implementation parameters, and development of a structured reporting template with design visualization to increase transparency of reporting and minimize misinterpretation.